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Orthopedics and pain management are the initial and most active research areas of Orthogen AG. Our methods find clinical application in these fields for over 25 years. We play a leading role in orthobiological discoveries and treatments.


Molecular orthopedics, as a major part of our research, has long shown that many orthopedic diseases are conditions not merely generated by mechanical wear and tear but result from a complex interplay of molecular and biochemical signals. 


Most orthopedic diseases are impacted by inflammation, other biomolecular changes and often regenerative deficiency in the short- or long-term. These factors are ascribed to diseases of any tissue type including joints, nerves, muscles, tendons. We strive for resolutions on biomolecular level and the restoration of tissue health; for this can result in clinical success with a pain alleviating, function and quality of life improving effect.

Joggen am Spreekanal

Orthopedics & Pain Management

Our goal is for athletes and best agers to be able to pursue their vocation, passions and hobbies without restriction and enjoy everyday life without pain.


Inflammation is not merely relevant to pain, but also directly relevant to the disease process and progression itself.

Peter Wehling, MD, PhD
CEO and Founder of Orthogen AG

To give an example: Osteoarthritis is a highly prevalent chronic disease with rising incidence, that could potentially affect anyone throughout lifetime. Osteoarthritis is commonly perceived as a widespread incurable but harmless condition. However, the disease actually constitutes an undervalued international health crisis. Osteoarthritis is associated with severe individual suffering, serious comorbidities, premature mortality and a large financial socioeconomic burden (OARSI White Paper, 2016).


Currently approved treatment options are largely palliative (suppressing symptoms) without a regenerative effect. In scientific consensus, the spectrum of currently available treatments is limited and lacks appropriate efficacy as well as safety. Many are associated with severe risks including cardiovascular diseases, gastric bleeding, persistent disability and premature death. Analgesics overuse cannot merely lead to severe consequences individually but also socioeconomically, as the opioid crisis has demonstrated.

We intend to address these issues with our platform technologies in a scientific, robust manner. 

Our research spans in Orthopedics & Pain Management the following fields:


Cartilage defects

Degenerative Spine diseases

Spinal nerve compression

Meniscus tears

Tendinopathies (tears and irritations)

Muscular tears

Autoimmune diseases (Rheumatoid arthritis, Bechterew’s disease)​

Generally speaking, the critical unmet medical need in orthopedic diseases –with osteoarthritis as an exemplar disease– needs to be addressed efficiently, at the core of the problem and not only by suppressing symptoms until surgery is said to be unavoidable.

As a rule, we strive to verify our researches. Our technologies are subject of various scientific studies as well as reports and discussions in specialist journals worldwide.

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